Formulation development of chitosan - based nanoparticles for delivery of a hydrophilic
نویسنده
چکیده
Introduction Coacervation as a technique for producing nanoparticles has many advantages. It involves only aqueous solvents and mild processing conditions and is therefore ideal for maintaining the stability of proteins and peptides. In this study, we examined the formulation of novel nanoparticles using chitosan (CS) in combination with sulfobutyl ether-7-β -cyclodextrin sodium (SB-CD) for delivery of hydrophilic peptides. The hexapeptide dalargin, a Leu-enkephalin analogue with opioid activity, was chosen as a model peptide.
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